Exploring the untapped pharmacological potential of imidazopyridazines.

ABSTRACT: Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

SUBMITTER: Malik MS 

PROVIDER: S-EPMC10823362 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature