Context-dependent environmental associations with endometrial cancer histotype and genotype.

ABSTRACT:

Objective

MLH1 loss due to MLH1 methylation, detected during Lynch syndrome screening, is one of the most common molecular changes in endometrial cancer. It is well established that environmental influences such as nutritional state can impact gene methylation, both in the germline and in a tumor. In colorectal cancer and other cancer types, aging is associated with changes in gene methylation. The objective of this study was to determine if there was an association between aging or body mass index on MLH1 methylation in sporadic endometrial cancer.

Methods

A retrospective review of patients with endometrial cancer was performed. Tumors were screened for Lynch syndrome via immunohistochemistry, with MLH1 methylation analysis performed when there was loss

SUBMITTER: Nakad Borrego S 

PROVIDER: S-EPMC10823374 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature