Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineages.

ABSTRACT:

Introduction

Recombination serves as a common strategy employed by RNA viruses for their genetic evolution. Extensive genomic surveillance during the COVID-19 pandemic has reported SARS-CoV-2 Recombinant strains indicating recombination events during the viral evolution. This study introspects the phenomenon of genome recombination by tracing the footprint of prominent lineages of SARS-CoV-2 at different time points in the context of on-going evolution and emergence of Recombinants.

Method

Whole genome sequencing was carried out for 2,516 SARS-CoV-2 (discovery cohort) and 1,126 (validation cohort) using nasopharyngeal samples collected between the time period of March 2020 to August 2022, as part of the genomic surveillance program. The sequences were classified according to

SUBMITTER: Ravi V 

PROVIDER: S-EPMC10823376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature