Prognostic significance of IL-18 in acute coronary syndrome patients.

ABSTRACT:

Background

After acute coronary syndrome (ACS), inflammation aids healing but may harm the heart. Interleukin (IL)-18 and IL-1β are pivotal proinflammatory cytokines released during pyroptosis, a process that initiates and sustains inflammation. This study aimed to evaluate the levels of circulating IL-18 and IL-1β during the progression of ACS and to determine their association with subsequent clinical events in ACS patients.

Hypothesis

Circulating levels of IL-18 and IL-1β are associated with subsequent clinical events in ACS patients.

Methods

Employing immunoassays, we examined plasma levels of IL-1β and IL-18 in 159 ACS patients and matched them with 159 healthy controls. The primary composite endpoint included recurrent unstable angina, myocardial infarction, hea

SUBMITTER: Xiong C 

PROVIDER: S-EPMC10823553 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature