Biomarkers to discriminate between aseptic loosened and stable total hip or knee arthroplasties: a systematic review.

ABSTRACT:

Background

Loosening is a major cause for failure of total hip and total knee arthroplasties (THAs/TKAs). Preemptive diagnostics of asymptomatic loosening could open strategies to prevent gross loosening. A multitude of biomarkers may discriminate between loosened and stable implants, but it is unknown which have the best performance. The present systematic review aimed to assess which biomarkers have shown the most promising results in discriminating between stable and aseptic loosened THAs and TKAs.

Methods

PubMed, Embase, Web of Science, Cochrane Library, and Academic Search Premier were systematically searched up to January 2020 for studies including THA/TKA and biomarkers to assess loosening. Two reviewers independently screened records, extracted data, and assessed the

SUBMITTER: Hasan S 

PROVIDER: S-EPMC10823569 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature