Dataset Information

Independent association of thigh muscle fat density with vascular events in Korean adults.

ABSTRACT:

Background

We aimed to explore the associations between thigh muscle fat density and vascular events.

Methods

A total of 3,595 adults (mean age, 57.2 years; women, 1,715 [47.7%]) without baseline cardiovascular events from the Korean Atherosclerosis Study-2 were included. Muscle and fat area at the mid-thigh level were measured by computed tomography (CT) using the following Hounsfield Unit range: 0-30 for low density muscle (LDM); 31-100 for normal density muscle (NDM); and - 250 to - 50 for fat.

Results

During a median follow-up period of 11.8 (4.3-13.9) years, vascular events occurred in 11.6% of men and 5.9% of women. Individuals with vascular events had a larger LDM area (men: 48.8 ± 15.5 cm² vs. 44.6 ± 14.5 cm²; women: 39.4 ± 13.2 cm² vs. 35.0 ± 11.8 cm², both P < 0.001) compared with those who did not have vascular events during the follow-up of at least 5 years. The LDM/NDM ratio was also independently associated with vascular events after adjusting for cardiometabolic risk factors. Moreover, the LDM/NDM ratio improved the prognostic value for vascular events when added to conventional risk factors.

Conclusions

The current study suggests that a higher thigh muscle fat infiltration is associated with an increased risk of developing vascular events among Korean adults.

SUBMITTER: Choe HJ

PROVIDER: S-EPMC10823598 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Independent association of thigh muscle fat density with vascular events in Korean adults.

Choe Hun Jee HJ Chang Won W Blüher Matthias M Heymsfield Steven B SB Lim Soo S

Cardiovascular diabetology 20240128 1

<h4>Background</h4>We aimed to explore the associations between thigh muscle fat density and vascular events.<h4>Methods</h4>A total of 3,595 adults (mean age, 57.2 years; women, 1,715 [47.7%]) without baseline cardiovascular events from the Korean Atherosclerosis Study-2 were included. Muscle and fat area at the mid-thigh level were measured by computed tomography (CT) using the following Hounsfield Unit range: 0-30 for low density muscle (LDM); 31-100 for normal density muscle (NDM); and - 250 ...[more]

PMID: 38281946

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Dataset Information

Independent association of thigh muscle fat density with vascular events in Korean adults.

Background

Methods

Results

Conclusions

Publications

Independent association of thigh muscle fat density with vascular events in Korean adults.

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