FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.

ABSTRACT:

Background

The development of radioresistance seriously hinders the efficacy of radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance occurs are still incompletely understood. The N⁶-Methyladenosine (m⁶A) modification of RNA is involved in cancer progression, but its role in lung cancer radioresistance remains elusive. This study aimed to identify m⁶A regulators involved in lung cancer radiosensitivity and further explore the underlying mechanisms to identify therapeutic targets to overcome lung cancer radioresistance.

Methods

Bioinformatic mining was used to identify the m⁶A regulator IGF2BP2 involved in lung cancer radiosensitivity. Transcriptome sequencing was used to explore the downstream fac

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10823633 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature