Differentially expressed long non-coding RNAs and mRNAs of cadmium exposure on learning disability of offspring rats.

ABSTRACT:

Background

Cadmium (Cd) exposure has been found to have detrimental effects on the development of the central nervous system and cognitive ability in children. However, there is ongoing debate regarding the impact of maternal Cd exposure on the cognitive ability of offspring. In this study, we aimed to investigate the mechanisms underlying the influence of maternal Cd exposure on the cognitive ability of offspring rats.

Methods

Here, we constructed a model of cadmium poisoning in first-generation rats through gavage. The cognitive and memory abilities of its offspring were evaluated by water maze experiment. Then, we used the gene chip to find out the key genes, and we performed qRT-PCR detection of these genes. Subsequently, enrichment analysis was employed to identify path

SUBMITTER: Liu H 

PROVIDER: S-EPMC10823636 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature