ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.

ABSTRACT:

Background

Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function variants of ASGR1 are associated with a favorable metabolic profile and reduced incidence of cardiovascular diseases. The molecular mechanisms by which ASGR1 could affect the onset of metabolic syndrome and obesity are unclear. Therefore, here we investigated the contribution of ASGR1 in the development of metabolic syndrome and obesity.

Methods

ASGR1 deficient mice (ASGR1^-/-) were subjected to a high-fat diet (45% Kcal from fat) for 20 weeks. The systemic metabolic profile, hepatic and visceral adipose tissue were characterized for metabolic and

SUBMITTER: Svecla M 

PROVIDER: S-EPMC10823681 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature