Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma.

ABSTRACT:

Background

Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to systematically investigate the genomic characterization and immunotherapy efficacy of MSI-H patients with CCA.

Methods

We enrolled 887 patients with CCA in this study. Tumor samples were collected for next-generation sequencing. Differences in genomic alterations between the MSI-H and microsatellite stability (MSS) groups were analyzed. We also investigated the survival of PD-1 inhibitor-based immunotherapy between two groups of 139 patients with advanced CCA.

Results

Differential genetic alterations between the MSI-H and MSS groups included mutations in AR

SUBMITTER: Yang X 

PROVIDER: S-EPMC10823746 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature