Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.

ABSTRACT:

Background

Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance of chronic symptomless infections that sustain malaria transmission.

Methods

Here, we determined the gene expression profiles of the parasite population and the corresponding host peripheral blood mononuclear cells (PBMCs) from 21 children (< 15 years). We compared children who were defined as uninfected, asymptomatic and those with febrile malaria.

Results

Children with asymptomatic infections had a parasite transcriptional profile characterized by a bias toward trophozoite stage (~ 12 h-post invasion) parasites and low parasite levels

SUBMITTER: Kimenyi KM 

PROVIDER: S-EPMC10823747 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature