Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics Databases.

ABSTRACT: Toxicogenomics databases are useful for understanding biological responses in individuals because they include a diverse spectrum of biological responses. Although these databases contain no information regarding immune cells in the liver, which are important in the progression of liver injury, deconvolution that estimates cell-type proportions from bulk transcriptome could extend immune information. However, deconvolution has been mainly applied to humans and mice and less often to rats, which are the main target of toxicogenomics databases. Here, we developed a deconvolution method for rats to retrieve information regarding immune cells from toxicogenomics databases. The rat-specific deconvolution showed high correlations for several types of immune cells between spleen and blood, and be

SUBMITTER: Morita K 

PROVIDER: S-EPMC10823770 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature