Translational models of addiction phenotypes to advance addiction pharmacotherapy.

ABSTRACT: Alcohol and substance use disorders are heterogeneous conditions with limited effective treatment options. While there have been prior attempts to classify addiction subtypes, they have not been translated into clinical practice. In an effort to better understand heterogeneity in psychiatric disorders, the National Institute for Mental Health Research Domain Criteria (RDoC) has challenged scientists to think beyond diagnostic symptoms and to consider the underlying features of psychopathology from a neuroscience-based framework. The field of addiction has grappled with this approach by considering several key constructs with the potential to capture RDoC domains. This critical review will focus on the efforts to apply translational models of addiction phenomenology in human clinical sample

SUBMITTER: Ray LA 

PROVIDER: S-EPMC10823887 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature