Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results in high-risk MM with limited treatment alternatives. Thus, there is an urgent need for identification and validation of potential treatments for this MM subtype. Microarray data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic targets.

Aim

To elucidate the molecular basis and search for potential effective drugs of t(4;14) MM subtype by employing a comprehensive approach.

Methods

The transcriptional signature of t(4;14) MM was sourced from t

SUBMITTER: Song Y 

PROVIDER: S-EPMC10823940 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature