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Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy.


ABSTRACT: The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC (J Clin Oncol 2019; 37: 3223-3233), NCT04165772 (N Engl J Med 2022; 386: 2363-2376), and PROSPECT (N Engl J Med 2023; 389: 322-334). In this review, we comprehensively assess these pivotal trials and offer additional insights into the evolving role of pelvic radiation in contemporary oncology.

SUBMITTER: Ke TW 

PROVIDER: S-EPMC10823942 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy.

Ke Tao-Wei TW   Liao Yu-Min YM   Chang Sheng-Chi SC   Lin Che-Hung CH   Chen William Tzu-Liang WT   Liang Ji-An JA   Chien Chun-Ru CR  

World journal of clinical oncology 20240101 1


The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC (<i>J Clin Oncol</i> 2019; 37: 3223-3233), NCT04165772 (<i>N Engl J Med</i> 2022; 386: 2363-2376), and PROSPECT (<i>N Engl J Med</i> 2023; 389: 322-334). In this review, we comprehensively assess these pivotal trials and offer additional insights into the evolving r  ...[more]

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