Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: protocol for the TEMPUS randomised controlled trial.

ABSTRACT:

Introduction

Metabolic dysfunction-associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. Implementing strategies based on an intermittent fasting approach and supervised exercise may mitigate the risks. This study aims to investigate the effects of a 12-week time-restricted eating (TRE) intervention combined with a supervised exercise intervention, compared with TRE or supervised exercise alone and with a usual-care control group, on hepatic fat (primary outcome) and cardiometabolic health (secondary outcomes) in adults with obesity.

Methods and analysis

An anticipated 184 adults with obesity (50% women) will be recruited from Granada (south of Spain) for this parallel-group,

SUBMITTER: Camacho-Cardenosa A 

PROVIDER: S-EPMC10824004 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature