NKG2A⁺CD8⁺ T cells infiltration determines immunosuppressive contexture and inferior response to immunotherapy in clear cell renal cell carcinoma.

ABSTRACT:

Background

Immunotherapy is gaining momentum, but current treatments have limitations in terms of beneficiaries. Clear cell renal cell carcinoma (ccRCC) harbors the highest expression of human leukocyte antigen E (HLA-E), ligand of NKG2A, among all solid tumors. In this study, we aim to investigate the role of NKG2A⁺CD8⁺ T cells in tumor microenvironment and its potential as a novel target in ccRCC.

Methods

This study included four independent cohorts, including 234 patients from Zhongshan cohort (ZSHC) who underwent partial or radical nephrectomy at Zhongshan Hospital, and 117 metastatic patients from metastatic Zhongshan cohort (ZSHC-metastatic renal cell carcinoma) who were treated with immune checkpoint inhibitor or tyrosine kinase inhibitor alone.

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10824007 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature