Multimodal profiling of chordoma immunity reveals distinct immune contextures.

ABSTRACT:

Background

Chordomas are rare cancers from the axial skeleton which present a challenging clinical management with limited treatment options due to their anatomical location. In recent years, a few clinical trials demonstrated that chordomas can respond to immunotherapy. However, an in-depth portrayal of chordoma immunity and its association with clinical parameters is still lacking.

Methods

We present a comprehensive characterization of immunological features of 76 chordomas through application of a multimodal approach. Transcriptomic profiling of 20 chordomas was performed to inform on the activity of immune-related genes through the immunologic constant of rejection (ICR) signature. Multidimensional immunophenotyping through imaging mass cytometry was applied to provide i

SUBMITTER: van Oost S 

PROVIDER: S-EPMC10824073 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature