Non-invasive myocardial work in aortic stenosis: validation and improvement in left ventricular pressure estimation.

ABSTRACT:

Aims

The non-invasive myocardial work index (MWI) has been validated in patients without aortic stenosis (AS). A thorough assessment of methodological limitations is warranted before this index can be applied to patients with AS.

Methods and results

We simultaneously measured left ventricular pressure (LVP) by using a micromanometer-tipped catheter and obtained echocardiograms in 20 patients with severe AS. We estimated LVP curves and calculated pressure-strain loops using three different models: (i) the model validated in patients without AS; (ii) the same model, but with pressure at the aortic valve opening (AVO) adjusted to diastolic cuff pressure; and (iii) a new model based on the invasive measurements from patients with AS. Valvular events were determined by echocardio

SUBMITTER: Ribic D 

PROVIDER: S-EPMC10824486 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature