Characterising depression trajectories in young people at high familial risk of depression.

ABSTRACT:

Background

Parental depression is a common and potent risk factor for depression in offspring. However, the developmental course of depression from childhood to early-adulthood has not been characterized in this high-risk group.

Methods

Using longitudinal data from 337 young people who had a parent with a history of recurrent major depressive disorder (MDD), we characterized trajectories of broadly defined depressive disorder using latent class growth analysis. We used clinical descriptions to further characterise trajectory classes.

Results

Two trajectory classes were identified: childhood-emerging (25 %) and adulthood-emerging (75 %). The childhood-emerging class showed high rates of depressive disorder from age 12.5, which persisted through the study period. The ad

SUBMITTER: Weavers B 

PROVIDER: S-EPMC10824668 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature