Multi-institutional experience of MR-guided stereotactic body radiation therapy for adrenal gland metastases.

ABSTRACT:

Purpose

While dose escalation is associated with improved local control (LC) for adrenal gland metastases (AGMs), the proximity of gastrointestinal (GI) organs-at-risk (OARs) limits the dose that can be safely prescribed via CT-based stereotactic body radiation therapy (SBRT). The advantages of magnetic resonance-guided SBRT (MRgSBRT), including tumor tracking and online plan adaptation, facilitate safe dose escalation.

Methods

This is a multi-institutional review of 57 consecutive patients who received MRgSBRT on a 0.35-T MR linac to 61 AGMs from 2019 to 2021. The Kaplan-Meier method was used to estimate overall survival (OS), progression-free survival (PFS), and LC, and the Cox proportional hazards model was utilized for univariate analysis (UVA).

Results

Median fol

SUBMITTER: Mills M 

PROVIDER: S-EPMC10824679 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature