Stability-indicating UPLC assay coupled with mass spectrometry for the analysis of vilanterol degradation products in human urine.

ABSTRACT: Vilanterol is a once-daily dose inhaler prescribed for asthma and chronic obstructive pulmonary disease. This study involved an investigation of vilanterol stability under acidic, basic, oxidative, thermal, and photolytic stress conditions. UPLC method was developed and validated for the analysis of vilanterol with its degradants. The drug was stable under photolytic and thermal stress conditions and degraded under acidic, basic, and oxidative stress conditions. Degradation kinetics was performed for acidic, basic and oxidative stress conditions. Kinetics parameters, K, half-life time (t_1/2) and shelf-life time (t₉₀) were assessed, and the degradation followed first order reaction. The method was linear from 0.10 to 100.00 µg mL^-1 with accuracy, inter-day a

SUBMITTER: Tarek M 

PROVIDER: S-EPMC10824719 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature