A home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells.

ABSTRACT: Translational research for the evaluation of physical activity habits and lifestyle modifications based on nutrition and exercise has recently gained attention. In this study, we evaluated the effects of serum samples obtained before and after a 12-week home-based lifestyle intervention based on nutrition and exercise in breast cancer survivors in terms of modulation of the tumorigenic potential of breast cancer cells. The home-based lifestyle intervention proposed in this work consisted of educational counselling on exercise and nutritional behaviors and in 12 weeks of structured home-based exercise. Triple-negative breast cancer cell line MDA-MB-231 was cultured in semi-solid medium (3D culture) with sera collected before (PRE) and after (POST) the lifestyle intervention program. Spheroi

SUBMITTER: Baldelli G 

PROVIDER: S-EPMC10824728 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature