Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development.

ABSTRACT: Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division. We conducted a genome-wide cytosine methylation analysis of 399 human kidney samples, along with single-nuclear open chromatin analysis on over 60,000 cells from 14 subjects, including controls, and diabetes and hypertension attributed chronic kidney disease (CKD) patients. We identified and validated differentially methylated positions associated with disease states, and discovered that nearly 30% of these alterations were influenced by underlying genetic variations, including variants known to be associated with kidney disease in genome-wide association studies. We also identified regions sho

SUBMITTER: Yan Y 

PROVIDER: S-EPMC10824731 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature