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Structure determination needs to go viral.

ABSTRACT: Viral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures. Here, data were collected from the Protein Data Bank to screen the available structures of viruses of interest to WHO. Excluding SARS-CoV-2 and HIV-1, less than 50 structures were found per year, indicating a lack of diversity. Efforts to determine viral structures are needed to increase preparedness for future public health challenges.

SUBMITTER: de Bastos Balbe E Gutierres M

PROVIDER: S-EPMC10824879 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Structure determination needs to go viral.

de Bastos Balbe E Gutierres Matheus M Pedebos Conrado C Bacaicoa-Caruso Paula P Ligabue-Braun Rodrigo R

Amino acids 20240129 1

Viral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures. Here, data were collected from the Protein Data Bank to screen the available structures of viruses of interest to WHO. Excluding SARS-CoV-2 and HIV-1, less than 50 structures were found per year, indicating a lack of diversity. Efforts to determine viral structures are needed to increase preparedness for future public ...[more]

PMID: 38286913

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