Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model.

ABSTRACT: Osteosarcoma (OS) is the most common malignancy in children and adolescents and has a high probability of recurrence and metastasis. A growing number of studies have shown that neutrophil extracellular traps (NETs) are strongly associated with cancer metastasis, but in osteosarcoma, genes associated with NETs that promote osteosarcoma recurrence and metastasis remain to be explored. We systematically investigated the gene expression patterns of NETs in OS samples from the GEO database. NETs molecular typing was evaluated based on NETs expression profiles, and the association between NETs molecular subtypes and immune microenvironment and metastatic features were explored. Ultimately, we constructed a signature model and column line graph associated with metastasis prediction and screened p

SUBMITTER: Tang H 

PROVIDER: S-EPMC10824883 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature