Effects of STN-DBS on cognition and mood in young-onset Parkinson's disease: a two-year follow-up.

ABSTRACT:

Background

The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on the cognition and mood of patients with PD are still not uniformly concluded, and young-onset Parkinson's disease (YOPD) is even less explored.

Objective

To observe the effectiveness of STN-DBS on the cognition and mood of YOPD patients.

Methods

A total of 27 subjects, with a mean age at onset of 39.48 ± 6.24 and age at surgery for STN-DBS of 48.44 ± 4.85, were followed up preoperatively and for 2 years postoperatively. Using the Unified Parkinson disease rating scale (UPDRS), H&Y(Hoehn and Yahr stage), 39-Item Parkinson's Disease Questionnaire (PDQ-39), Mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton depression scale (HAMD), Hamilton anxiety scale (H

SUBMITTER: Hong J 

PROVIDER: S-EPMC10824910 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature