Sister haplotypes and recombination disequilibrium: a new approach to identify associations of haplotypes with complex diseases.

ABSTRACT: Haplotype-based association analysis has several advantages over single-SNP association analysis. However, to date all haplotype-disease associations have not excluded recombination interference among multiple loci and hence some results might be confounded by recombination interference. Association of sister haplotypes with a complex disease, based on recombination disequilibrium (RD) was presented. Sister haplotypes can be determined by translating notation of DNA base haplotypes to notation of genetic genotypes. Sister haplotypes provide haplotype pairs available for haplotype-disease association analysis. After performing RD tests in control and case cohorts, a two-by-two contingency table can be constructed using sister haplotype pair and case-control pair. With this standard two-by-t

SUBMITTER: Liao SY 

PROVIDER: S-EPMC10825010 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature