Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study.

ABSTRACT:

Background

Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.

Methods

A case-control study was conducted, including 454 TGCT cases aged 18-45 from 20 French university hospitals, matched to 670 controls based on region and year of birth. Data collected from participants included parental jobs at birth coded according to the International Standard Classification of Occupation-1968 and the French nomenclature of activities-1999. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regress

SUBMITTER: Paul A 

PROVIDER: S-EPMC10825020 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature