Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.

ABSTRACT: Compelling evidence shows that the frequency of T cells in the tumor microenvironment correlates with prognosis as well as response to immunotherapy. However, considerable heterogeneity exists within tumor-infiltrating T cells, and significance of their genomic and transcriptomic landscape on clinical outcomes remains to be elucidated. Signaling lymphocyte activation molecule 6 (SLAMF6) is expressed on intra-tumoral progenitor-exhausted T cells, which exhibit the capacity to proliferate, self-renew and produce terminally-exhausted T cells in pre-clinical models and patients. Here, we investigated the impact of SLAMF6 expression on prognosis in two immunologically different tumor types using publicly available databases. Our findings demonstrate that high SLAMF6 expression is associated wit

SUBMITTER: Oba T 

PROVIDER: S-EPMC10825192 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature