Explorative multifactor approach for investigating global survival mechanisms of Campylobacter jejuni under environmental conditions.

ABSTRACT: Explorative approaches such as DNA microarray experiments are becoming increasingly important in microbial research. Despite these major technical advancements, approaches to study multifactor experiments are still lacking. We have addressed this problem by using rotation testing and a novel multivariate analysis of variance (MANOVA) approach (50-50 MANOVA) to investigate interacting experimental factors in a complex experimental design. Furthermore, a new rotation testing based method was introduced to calculate false-discovery rates for each response. This novel analytical concept was used to investigate global survival mechanisms in the environment of the major food-borne pathogen C. jejuni. We simulated nongrowth environmental conditions by investigating combinations of the factors tem

SUBMITTER: Moen B 

PROVIDER: S-EPMC1082531 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature