Comprehensive evaluation of smoking exposures and their interactions on DNA methylation.

ABSTRACT:

Background

Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero smoking exposure, and effects of environmental tobacco smoke (ETS).

Methods

We meta-analysed data from up to 15,014 adults across 5 cohorts with DNA methylation measured in blood using Illumina's EPIC array for current smoking (2560 exposed), quit < 1 year (500 exposed), in utero (286 exposed), and ETS exposure (676 exposed). We also evaluated the interaction of current smoking with sex or diet (fibre, folate, and vitamin C).

Findings

Using false discovery rate (FDR < 0.05), 65,857 CpGs were differentially methylated in relation to current smoking

SUBMITTER: Hoang TT 

PROVIDER: S-EPMC10825325 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature