γδ T cells mediate robust anti-HIV functions during antiretroviral therapy regardless of immune checkpoint expression.

ABSTRACT:

Objectives

Although antiretroviral therapy (ART) efficiently suppresses HIV viral load, immune dysregulation and dysfunction persist in people living with HIV (PLWH). γδ T cells are functionally impaired during untreated HIV infection, but the extent to which they are reconstituted upon ART is currently unclear.

Methods

Utilising a cohort of ART-treated PLWH, we assessed the frequency and phenotype, characterised in vitro functional responses and defined the impact of immune checkpoint marker expression on effector functions of both Vδ1 and Vδ2 T cells. We additionally explore the in vitro expansion of Vδ2 T cells from PLWH on ART and the mechanisms by which such expanded cells may sense and kill HIV-infected targets.

Results

A matured NK cell-like pheno

SUBMITTER: Field KR 

PROVIDER: S-EPMC10825377 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature