Higher Virulence Renders K2 Klebsiella pneumoniae a Stable Share Among Those from Pyogenic Liver Abscess.

ABSTRACT:

Objective

To explore why serotype K2 accounts for a stable share in Klebsiella pneumoniae from pyogenic liver abscess (PLA).

Methods

Totally 15 K2 K. pneumoniae strains from PLA, 21 K2 from non-PLA, and 31 K1 from PLA were collected from China. Sequence typing, molecular serotyping, regular PCR, and Galleria mellonella lethality were performed. A total of 12 virulence genes were detected: peg-344, allS, p-rmpA, p-rmpA2, c-rmpA, fimH, mrkD, iucA, iroN, irp2, entB, and wzi. The differences between K2 K. pneumoniae strains from PLA and non-PLA were investigated along with K1 ones.

Results

Significant differences were found between K2 strains from PLA and non-PLA for the rates of virulence genes peg-344 and iucA. The

SUBMITTER: Dong M 

PROVIDER: S-EPMC10825582 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature