The specificity of the auditory P300 responses and its association with clinical outcomes in youth with psychosis risk syndrome.

ABSTRACT:

Background

Schizophrenia often occurs in youth, and psychosis risk syndrome (PRS) occurs before the onset of psychosis. Assessing the neuropsychological abnormalities of PRS individuals can help in early identification and active intervention of mental illness. Auditory P300 amplitude defect is an important manifestation of attention processing abnormality in PRS, but it is still unclear whether there are abnormalities in the attention processing of rhythmic compound tone stimuli in PRS individuals, and whether the P300 amplitude induced by these stimuli is specific to PRS individuals and related to their clinical outcomes.

Methods

In total, 226 participants, including 122 patients with PRS, 51 patients with emotional disorders (ED), and 53 healthy controls (HC) were assesse

SUBMITTER: Hou Y 

PROVIDER: S-EPMC10825643 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature