Criterion Validation of Tau PET Staging Schemes in Relation to Cognitive Outcomes.

ABSTRACT:

Background

Utilization of NIA-AA Research Framework requires dichotomization of tau pathology. However, due to the novelty of tau-PET imaging, there is no consensus on methods to categorize scans into "positive" or "negative" (T+ or T-). In response, some tau topographical pathologic staging schemes have been developed.

Objective

The aim of the current study is to establish criterion validity to support these recently-developed staging schemes.

Methods

Tau-PET data from 465 participants from the Alzheimer's Disease Neuroimaging Initiative (aged 55 to 90) were classified as T+ or T- using decision rules for the Temporal-Occipital Classification (TOC), Simplified TOC (STOC), and Lobar Classification (LC) tau pathologic schemes of Schwarz, and Chen staging scheme. Subseq

SUBMITTER: Hammers DB 

PROVIDER: S-EPMC10825758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature