Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial.

ABSTRACT:

Importance

Electronic cigarettes (ECs) are often used by smokers as an aid to stopping smoking, but evidence is limited regarding their efficacy compared with nicotine replacement therapy (NRT), and no evidence is available on how their efficacy compares with that of varenicline.

Objective

To evaluate whether ECs are superior to NRT and noninferior to varenicline in helping smokers quit.

Design, setting, and participants

This was a randomized clinical trial conducted at 7 sites in China and including participants who were smoking at least 10 cigarettes per day and motivated to quit, not using stop-smoking medications or EC, and willing to use any of the study products. Participants were first recruited in May 2021, and data analysis was conducted in December 2022.

SUBMITTER: Lin HX 

PROVIDER: S-EPMC10825782 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature