A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells.

ABSTRACT: Air pollution is a public health threat and global epidemiological studies have shown that ambient air pollutants are closely related to various poor health conditions, including neurodegenerative diseases. Here, we evaluated the toxic effects and the underlying mechanisms of fine airborne particulate matter (PM_2.5) on human glioblastoma LN-229 cells. Our results showed that exposure of LN-229 cells to PM_2.5 (≥ 200 μg/mL) significantly reduced cell viability. PM_2.5 exposure increased autophagy, apoptosis, and ROS production in the cells. Pre-treatment with a ROS scavenger, catalase, or depletion of mtDNA (ρ⁰ cells) abolished PM_2.5-induced autophagy and apoptosis. PM_2.5 exposure also activated MAPK signals in cells, which wer

SUBMITTER: Yuan J 

PROVIDER: S-EPMC10825875 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature