Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence.

ABSTRACT:

Objective

We performed a systematic review of the epidemiology literature to identify the male reproductive effects associated with phthalate exposure.

Data sources and study eligibility criteria

Six phthalates were included in the review: di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of male reproductive effects in humans, and outcomes were selected for full systematic review based on data availability.

Study evaluation and synthesis methods

For each outcome, studies were evaluated using criteria defined a priori for risk of bias and sensitivity by

SUBMITTER: Radke EG 

PROVIDER: S-EPMC10825890 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature