The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage.

ABSTRACT:

Background

Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression. The serum succinate level is consistently elevated in individuals with diabetes and obesity, both of which are critical factors contributing to CKD. However, it remains unclear whether elevated succinate levels can mediate M2 polarization of macrophages and contribute to renal interstitial fibrosis.

Methods

Male C57/BL6 mice were administered water supplemented with 4% succinate for 12 weeks to assess its impact on renal interstitial fibrosis. Additionally, the significance of macrophages was confirmed in vivo by using clodronate liposomes to deplete them. Furthe

SUBMITTER: Pu M 

PROVIDER: S-EPMC10826041 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature