Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells.

ABSTRACT:

Background

Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM is so difficult to treat is that it is highly infiltrative. Migrasomes are newly discovered membrane structures observed in migrating cells. Thus, they can be generated from GBM cells that have the ability to migrate along the brain parenchyma. However, the function of migrasomes has not yet been elucidated in GBM cells.

Results

Here, we describe the composition and function of migrasomes generated along with GBM cell migration. Proteomic analysis revealed that LC3B-positive autophagosomes were abundant in the migrasomes of GBM cells. An increased number of migrasomes was observed following treatment with chloroquine (CQ) or inhibition of the expression of S

SUBMITTER: Lee SY 

PROVIDER: S-EPMC10826056 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature