Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models.

ABSTRACT:

Introduction

17β-Estradiol (E2) is a sex hormone that has been previously demonstrated to have neurotherapeutic effects on animal models of Alzheimer's disease (AD). However, clinical trials on E2 replacement therapy for preventing AD onset yielded inconsistent results. Therefore, it is imperative to clarify the therapeutic effects of E2 on human cells. In this study, we utilized induced pluripotent stem cells (iPSCs) derived from multiple AD donors to explore the therapeutic effects of E2 on the in vitro model of human cells.

Methods

We conducted a systematic review and meta-analysis using a random-effects model of the previously reported AD clinical trials to summarize the effects of E2 replacement therapy on AD prevention. Subsequently, we induced iPSCs from the do

SUBMITTER: Supakul S 

PROVIDER: S-EPMC10826128 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature