MicroRNA expression signature as a biomarker in the diagnosis of nodal T-cell lymphomas.

ABSTRACT:

Background

The diagnosis of T-cell lymphomas is typically established through a multiparameter approach that combines clinical, morphologic, immunophenotypic, and genetic features, utilizing a variety of histopathologic and molecular techniques. However, accurate diagnosis of such lymphomas and distinguishing them from reactive lymph nodes remains challenging due to their low prevalence and heterogeneous features, hence limiting the confidence of pathologists. We investigated the use of microRNA (miRNA) expression signatures as an adjunctive tool in the diagnosis and classification of T-cell lymphomas that involve lymph nodes. This study seeks to distinguish reactive lymph nodes (RLN) from two types of frequently occurring nodal T-cell lymphomas: nodal T-follicular helper (TFH) cel

SUBMITTER: Bin Masroni MS 

PROVIDER: S-EPMC10826179 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature