Coexistence of meningioma and craniofacial fibrous dysplasia: a case series of clinicopathological study and literature review.

ABSTRACT:

Background

The co-existence of meningioma and craniofacial fibrous dysplasia (CFD) is rare. Due to the similar radiological characteristics, it is challenging to differentiate such co-existence from solitary hyperostotic meningioma resulting in a dilemma of prompt diagnosis and appropriate intervention.

Method

We conducted a retrospective review of the data from 21 patients with concomitant meningioma and CFD who were treated at Beijing Tiantan Hospital from 2003 to 2021. We summarized their clinicopathological features and performed a comprehensive literature review. Additionally, we tested the characteristic pathogenic variants in exon 8 and 9 of GNAS gene and the expression of corresponding α-subunit of the stimulatory G protein (Gα_s) related to CFD to explore

SUBMITTER: Song X 

PROVIDER: S-EPMC10826192 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature