Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population.

ABSTRACT:

Background

NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU admission in a mixed ICU population and to relate these to AKI severity during ICU stay. Via these means we aimed to bring clarity to the previously reported heterogeneity of these renal biomarkers.

Methods

Prospective Observation Cohort. Consecutive patients admitted to adult ICU at an academic hospital in the Netherlands between 18-02-2014 and 31-03-2014 were included. Urine output, serum creatinine, plasma NGAL and CysC were recorded during the first seven days of ICU admission. Biomarker

SUBMITTER: Jou-Valencia D 

PROVIDER: S-EPMC10826252 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature