Identification of biomarker candidates for exfoliative glaucoma from autoimmunity profiling.

ABSTRACT:

Background

Exfoliative glaucoma (XFG) is a subtype of open-angle glaucoma characterized by distinctive extracellular fibrils and a yet unknown pathogenesis potentially involving immune-related factors. The aim of this exploratory study was to identify biomarkers for XFG using data from autoimmunity profiling performed on blood samples from a Scandinavian cohort of patients.

Methods

Autoantibody screening was analyzed against 258 different protein fragments in blood samples taken from 30 patients diagnosed with XFG and 30 healthy donors. The 258 protein fragments were selected based on a preliminary study performed on 3072 randomly selected antigens and antigens associated with the eye. The "limma" package was used to perform moderated t-tests on the proteomic data to identif

SUBMITTER: Potter R 

PROVIDER: S-EPMC10826272 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature