Tumorous IRE1α facilitates CD8⁺T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma.

ABSTRACT:

Background

Tumor cells frequently suffer from endoplasmic reticulum (ER) stress. Previous studies have extensively elucidated the role of tumorous unfolded protein response in melanoma cells, whereas the effect on tumor immunology and the underlying mechanism remain elusive.

Methods

Bioinformatics, biochemical assays and pre-clinical mice model were employed to demonstrate the role of tumorous inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) in anti-tumor immunity and the underlying mechanism.

Results

We firstly found that IRE1α signaling activation was positively associated with the feature of tumor-infiltrating lymphocytes. Then, pharmacological ER stress induction by HA15 exerted prominent anti-tumor effect in immunocompetent mice and was highly

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10826282 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature