Clinical human metapneumovirus isolates show distinct pathogenesis and inflammatory profiles but similar CD8⁺ T cell impairment.

ABSTRACT: Human metapneumovirus (HMPV) is a negative-sense single-stranded RNA virus in the Pneumoviridae family and a leading cause of acute upper and lower respiratory infections, particularly in children, immunocompromised patients, and the elderly. Although nearly every person is infected with HMPV during early childhood, re-infections occur often, highlighting difficulty in building long-term immunity. Inflammatory responses, including PD-1-mediated impairment of virus-specific CD8⁺ T cells (T_CD8), contribute to HMPV disease severity. HMPV strains are divided into four lineages: A1, A2, B1, and B2. However, little is known about immune responses to different viral subtypes. Here, we characterize responses to four HMPV clinical isolates-TN/94-344 (A1), TN/94-49 (A2),

SUBMITTER: Sojati J 

PROVIDER: S-EPMC10826344 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature