Phylogenetic and functional analyses of N⁶-methyladenosine RNA methylation factors in the wheat scab fungus Fusarium graminearum.

ABSTRACT: In eukaryotes, N⁶-methyladenosine (m⁶A) RNA modification plays a crucial role in governing the fate of RNA molecules and has been linked to various developmental processes. However, the phyletic distribution and functions of genetic factors responsible for m⁶A modification remain largely unexplored in fungi. To get insights into the evolution of m⁶A machineries, we reconstructed global phylogenies of potential m⁶A writers, readers, and erasers in fungi. Substantial copy number variations were observed, ranging from up to five m⁶A writers in early-diverging fungi to a single copy in the subphylum Pezizomycotina, which primarily comprises filamentous fungi. To characterize m⁶A factors in a phytopathogenic fun

SUBMITTER: Kim H 

PROVIDER: S-EPMC10826363 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature