Calcineurin-dependent contributions to fitness in the opportunistic pathogen Candida glabrata.

ABSTRACT: The protein phosphatase calcineurin is vital for the virulence of the opportunistic fungal pathogen Candida glabrata. The host-induced stresses that activate calcineurin signaling are unknown, as are the targets of calcineurin relevant to virulence. To potentially shed light on these processes, millions of transposon insertion mutants throughout the genome of C. glabrata were profiled en masse for fitness defects in the presence of FK506, a specific inhibitor of calcineurin. Eighty-seven specific gene deficiencies depended on calcineurin signaling for full viability in vitro both in wild-type and pdr1∆ null strains lacking pleiotropic drug resistance. Three genes involved in cell wall biosynthesis (FKS1, DCW1, FLC1) possess co-essenti

SUBMITTER: Pavesic MW 

PROVIDER: S-EPMC10826367 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature